"Unless we act the NHS will not be able to look after the increasing number of people who are falling seriously ill, even with the extra 5,000 beds that we have available for this winter," says Mr Drakeford.
The two-week firebreak will start at 18:00 on Friday 23 October.
It will include the half-term holiday and end on Monday 9 November.
"This firebreak is the shortest we can make but that means it will be sharp and deep in order to have the maximum impact," said Mr Drakeford.
He said from 23 October to 9 November:
everyone in Wales will be required to stay at home. This means working from home wherever that is possible
All non-essential retail, leisure and tourism businesses will close, as well as community centres, libraries and places of worship (except for funerals and wedding ceremonies)
Hospitality outlets such as bars and restaurants will also close, apart from for takeaways
Close-contact services like hairdressers and beauticians will close.
To all Clients of Boo hair that have appointments booked post Friday the 23rd of October. Appointments will be rolled over to the reopening date of Monday the 9th of November. I will be in direct contact with everyone who have appointments booked during the shut down period.
I appreciate your patience and Loyalty during this time.